Miller is both a studio artist and has 20 years of project management, arts administration, and exhibition planning experience.

Primarily focusing on works on paper, Adrienne Miller’s studio practice explores the use of symbolic landscapes and abstract interior spaces to reflect on the meaning of physical and mental boundaries and her personal research in psychology, the American relationship to natural spaces, suburban expansion and the history of property ownership.

She is currently employed as the Exhibition and Publication Manager at the Speed Museum in Louisville, Kentucky. Since 2017, she has managed the presentation of all exhibitions at the Speed Art Museum in Louisville, Kentucky- recently including Isabelle de Borchgrave: Fashioning Art from Paper, Supernatural America: The Paranormal in American Art, Warhol: Revelation, Sanford Biggers: Codeswitch and Alphonse Mucha: Art Nouveau Visionary.

In 2020 she bought and rehabbed an old pawn shop building on historic Frankfort Avenue in Louisville, creating a permanent home for the large amount of letterpress equipment she shares with her freelance-designer husband as well as their community gallery space, Friend of Mine which opens in 2025.